Table 3 Factors Associated with Poor Overall Survival.

From: Predictive and Prognostic Value of 18F-fluorodeoxyglucose Uptake Combined with Thymidylate Synthase Expression in Patients with Advanced Non-Small Cell Lung Cancer

 

Univariate

Multivariate

HR

95% CI

P-value

HR

95% CI

P-value

Male (vs. female)

2.14

1.41–3.27

0.004

1.22

0.57–2.62

0.602

EGFR wild-type (vs. mutation)

2.69

1.65–4.40

<0.001

2.00

1.15–3.48

0.014

TS-positive (vs. TS-negative)

2.11

1.42–3.15

<0.001

1.69

1.05–2.72

0.030

Ever smoked (vs. never smoker)

2.18

1.44–3.31

<0.001

1.61

0.79–3.41

0.214

Age ≥65 years (vs. <65 years)

1.99

1.35–2.94

<0.001

1.94

1.23–3.07

0.004

High TLG

1.94

1.23–3.06

0.004

1.65

1.04–2.63

0.035

AP group (vs. GP group)

1.01

0.68–1.48

0.974

   

ALK rearrangement

0.62

0.23–1.68

0.345

   
  1. HR, hazard ratio; CI, confidence interval; EGFR, epidermal growth factor receptor; TS, thymidylate synthase; TLG, total lesion glycolysis; AP, pemetrexed/cisplatin-treated; GP, gemcitabine/cisplatin-treated; ALK, anaplastic lymphoma kinase.
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