Table 1 Functional and structural parameters of mice at study end.
From: A new, easily generated mouse model of diabetic kidney fibrosis
n | Akita−/− Ren−/− | Akita−/− Ren+/− | Akita+/− Ren−/− | Akita+/− Ren+/− |
|---|---|---|---|---|
16 | 10 | 6 | 4 | |
Phenotype | Non-diabetic, Normotensive | Non-diabetic, Hypertensive | Diabetic, Normotensive | Diabetic, Hypertensive |
Plasma glucose (mmol/L) | 9.1 ± 0.6 | 8.8 ± 0.7 | 30.2 ± 1.4a,b | 29.0 ± 1.6a,b |
HbA1c (%) | 5.1 ± 0.1 | 4.9 ± 0.1 | 13.4 ± 0.4a,b | 13.0 ± 0.0a,b |
Body weight (g) | 44.2 ± 1.5 | 40.8 ± 1.1 | 35.8 ± 1.7a | 34.2 ± 0.9a,b |
Systolic blood pressure (mm Hg) | 100 ± 4 | 151 ± 5a | 99 ± 9b | 145 ± 14a,c |
Serum creatinine (μmol/L) | 32.9 ± 2.3 | 35.8 ± 4.2 | 58.8 ± 4.8a,b | 70.2 ± 3.1a,b |
24 hour urine volume (mL) | 2.2 ± 0.7 | 2.8 ± 0.8 | 51.0 ± 6.4a,b | 33.2 ± 2.6a,b,c |
Right kidney weight (μg) | 245 ± 10 | 290 ± 20 | 492 ± 54a,b | 445 ± 43a,b |
Tibia length (mm) | 19.9 ± 0.4 | 19.1 ± 0.6 | 18.5 ± 0.6 | 18.2 ± 0.6 |
Right kidney/tibia length (μg/mm) | 12.3 ± 0.4 | 15.2 ± 1.0 | 27.0 ± 3.8a,b | 24.4 ± 2.2a,b |
Right kidney/body weight (μg/g) | 5.6 ± 0.2 | 7.2 ± 0.6 | 13.7 ± 1.4a,b | 13.0 ± 1.4a,b |
