Table 2 Changes in Dry Eye Parameters and Meibomian Gland Dysfunction Parameters between Preoperative and 4 and 12 Weeks After Cataract Surgery.

From: Effects of Preservative-free 3% Diquafosol in Patients with Pre-existing Dry Eye Disease after Cataract Surgery: A Randomized Clinical Trial

 

Group 1 (38 eyes)

Group 2 (41 eyes)

Group 3 (38 eyes)

P-value

TBUT (sec)

  Preoperative

4.6 ± 2.2

5.0 ± 2.5

4.6 ± 1.8

0.925

  4wks

6.3 ± 3.6*

7.0 ± 2.8*

3.7 ± 1.4‡§

<0.001

  12wks

6.5 ± 3.5*

5.0 ± 2.8

4.7 ± 2.3‡

0.038

Schirmer test (mm)

  Preoperative

15.5 ± 8.6

13.1 ± 8.7

11.5 ± 7.6

0.076

  4wks

13.7 ± 8.9

11.4 ± 8.0

10.6 ± 6.1

0.389

  12wks

12.2 ± 9.0

13.2 ± 9.3

14.2 ± 8.6

0.396

Corneal staining score

  Preoperative

0.66 ± 1.07

0.63 ± 0.89

0.84 ± 0.59

0.051

  4wks

0.24 ± 0.60*

0.29 ± 0.51*

0.29 ± 0.52*

0.693

  12wks

0.23 ± 0.43*

0.43 ± 0.57*

0.26 ± 0.45*

0.263

OSDI

  Preoperative

22.10 ± 12.94

23.49 ± 11.38

22.30 ± 9.01

0.836

  4wks

14.99 ± 10.42*

15.00 ± 9.19*

21.29 ± 12.57‡§

0.015

  12wks

10.35 ± 10.55*

15.43 ± 12.24*

17.63 ± 11.45* ‡

0.037

LLT (nm)

  Preoperative

80.82 ± 18.77

86.00 ± 19.17

82.25 ± 20.10

0.484

  4wks

76.24 ± 21.32

84.70 ± 21.66

86.03 ± 18.15

0.070

  12wks

83.29 ± 19.91

85.23 ± 22.70

84.55 ± 22.12

0.749

MGD stage

  Preoperative

2.61 ± 1.11

2.44 ± 1.18

2.34 ± 1.10

0.407

  4wks

2.27 ± 1.07*

1.90 ± 1.39*

2.58 ± 1.13

0.071

  12wks

1.71 ± 1.19*

2.13 ± 1.07

2.68 ± 1.07‡

0.003

Lid margin abnormality

  Preoperative

2.58 ± 1.00

2.34 ± 1.37

2.03 ± 1.20

0.174

  4wks

2.08 ± 1.06*

1.80 ± 1.19*

2.21 ± 1.26

0.246

  12wks

1.71 ± 1.10*

2.13 ± 1.17

2.06 ± 1.04

0.285

Meibomian gland expressibility

  Preoperative

1.84 ± 1.05

1.88 ± 1.01

1.61 ± 0.95

0.327

  4wks

1.41 ± 0.83

1.02 ± 0.99*

1.55 ± 0.98§

0.043

  12wks

1.00 ± 0.89*

1.33 ± 0.84*

1.88 ± 0.88‡§

<0.001

Meibum quality

  Preoperative

12.18 ± 5.92

10.22 ± 5.73

10.16 ± 6.77

0.327

  4wks

10.14 ± 3.74*

8.05 ± 6.29* †

11.05 ± 4.75§

0.007

  12wks

6.55 ± 4.15*

9.86 ± 4.54†

12.94 ± 6.02* ‡§

<0.001

Meibomian gland dropout

  Preoperative

1.11 ± 0.73

1.37 ± 1.07

1.47 ± 1.13

0.467

  4wks

1.09 ± 0.75

1.34 ± 0.99

1.42 ± 1.18

0.547

  12wks

1.06 ± 0.74

1.44 ± 1.01

1.50 ± 1.16

0.234

  1. Data are presented as means ± standard deviation. TBUT = tear breakup time; OSDI = Ocular Surface Disease Index; LLT = lipid layer thickness; MGD = meibomian gland dysfunction. P-value indicates the statistical analysis among the three groups. *Indicates a statistically significant compared with preoperative value; †indicates a statistically significant difference between groups A and B in post hoc analysis; ‡indicates a statistically significant difference between groups A and C in post hoc analysis; §indicates a statistically significant difference between groups B and C in post hoc analysis.
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