Figure 2 | Scientific Reports

Figure 2

From: Pharmacological mTOR targeting enhances the antineoplastic effects of selective PI3Kα inhibition in medulloblastoma

Figure 2

PIK3CA expression is elevated in the SHH-subgroup and correlates with GLI1 expression in medulloblastoma. (A) PIK3CA expression was analyzed in different medulloblastoma subgroups from the Northcott_2012 dataset, downloaded from the GlioVis portal (http://gliovis.bioinfo.cnio.es/) and subjected to analysis in GraphPad Prism 7.0. Unpaired one-way ANOVA, ****P ≤ 0.0001. (B) Gene expression data from the Northcott_2012 dataset were downloaded from the GlioVis portal and GraphPad Prism 7.0 was used for correlation analysis to compare PIK3CA expression with GLI1. Pearson’s correlation coefficient is shown, ****P ≤ 0.0001. (C) Medulloblastoma patient data from the Northcott_2012 dataset were subjected to KEGG pathway enrichment analysis for GLI1 using the GlioVis portal (http://gliovis.bioinfo.cnio.es/). Bubble chart shows enrichment for the given pathway, where each point represents the enrichment level, the colour corresponds to the adjusted P-value (P.adjust), and the size corresponds to the number of genes enriched (Count). Y-axis label represents pathway (see bottom panel for detailed name of pathways), and X-axis label represents enrichment factor (amount of differentially expressed genes enriched in the pathway over amount of all genes in background gene set).

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