Figure 5
Dual PI3Kα and mTOR inhibition reduces tumour growth in a medulloblastoma flank tumour xenograft. (A) Tumour volumes from a flank xenograft mouse model are shown. Nude mice were injected subcutaneously into the left flank with DAOY cells (5 × 106 cells/mouse). Once mice showed palpable tumours, mice were randomized into vehicle control (VC; n = 10), alpelisib (50 mg/kg; n = 9), OSI-027 (25 mg/kg; n = 9) or combination (alpelisib and OSI-027; n = 10) groups. Mice were treated by oral gavage for 5 days, then 2 days rest followed by another 4 days of treatment (indicated by purple boxes). Two-way ANOVA for day 55; **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. (B) Body weight of mice from flank tumour xenograft experiment. Mouse body weight from experiment in A was recorded every other day throughout the study.
