Table 2 Warfarin sensitivity based on genotypes and three ranges of recommended warfarin doses (mg/week) from the USA FDA drug label (COUMADIN, Reference ID: 3022954).
VKORC1 | CYP2C9 | |||||
|---|---|---|---|---|---|---|
*1/*1 | *1/*2 | *1/*3 | *2/*2 | *2/*3 | *3/*3 | |
G/G | Normal (35–49) | Normal (35–49) | Sensitive (21–28) | Sensitive (21–28) | Sensitive (21–28) | Very Sensitive (3.5–14) |
A/G | Normal (35–49) | Sensitive (21–28) | Sensitive (21–28) | Sensitive (21–28) | Very Sensitive (3.5–14) | Very Sensitive (3.5–14) |
A/A | Sensitive (21–28) | Sensitive (21–28) | Very Sensitive (3.5–14) | Very Sensitive (3.5–14) | Very Sensitive (3.5–14) | Very Sensitive (3.5–14) |
