Table 3 Validation of the risk scoring system.

From: Development and Validation of a Risk Scoring System for Cephamycin-Associated Hemorrhagic Events

Predictor Variable

Risk Score

AUROC (95% CI)

Derivation

Validation

Study antibiotics

Reference

0

0.6169 (0.5918–0.6420)

0.5953 (0.5610–0.6295)

Cephamycins§

1

  

Chronic hepatic disease

No

0

0.5631 (0.5428–0.5833)

0.5645 (0.5367–0.5924)

Yes

1

  

Age (years)

<65

0

0.5718 (0.5463–0.5973)

0.6000 (0.5677–0.6324)

≥65

1

  

Bleeding tendency*

No

0

0.6581 (0.6321–0.6842)

0.5967 (0.5628–0.6305)

Yes

2

  

History of bleeding ¥

No

0

0.7097 (0.6837–0.7358)

0.6839 (0.6495–0.7184)

Yes

4

  

Total score

0~9

0.8035 (0.7794–0.8275)

0.7550 (0.7198–0.7902)

Hosmer-Lemeshow test

 

p = 0.1044

p = 0.0641

  1. Amoxicillin/clavulanic acid, ampicillin/sulbactam, cefuroxime, cefotaxime, ceftriaxone; §Cefmetazole, flomoxef; ¥During previous 180 days; *Indicated by prescriptions of proton pump inhibitors/tranexamic acid/clotting factors during prior 7 days.