Figure 1 | Scientific Reports

Figure 1

From: Pro-Cellular Exhaustion Markers are Associated with Splenic Microarchitecture Disorganization and Parasite Load in Dogs with Visceral Leishmaniasis

Figure 1

Identification of (A–C) CD4+, (D–F) CD8+, and (G–I) CD21+ cells by immunohistochemistry and quantitative analysis of the spleen of dogs naturally infected with L. infantum grouped according to the disorganization of the splenic white pulp and the parasite load: (B) percentage of CD4+ cells, (C) CD4+ cells/mm2, (E) percentage of CD8+ cells, (F) CD8+ cells/mm2, (H) percentage of CD21+ cells, and (I) CD21+ cells/mm2. Mann-Whitney test: (B) *p = 0.019; (C) *p = 0.0036, **p = 0.0383. Kruskal-Wallis test: (B) p = 0,031; (C) p = 0.021.

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