Figure 3 | Scientific Reports

Figure 3

From: Pro-Cellular Exhaustion Markers are Associated with Splenic Microarchitecture Disorganization and Parasite Load in Dogs with Visceral Leishmaniasis

Figure 3

Identification of (A–C) TIM-3+ and (D–F) CTLA-4+ cells by immunohistochemistry and quantitative analysis of exhausted cells in the spleen of dogs naturally infected with L. infantum grouped according to the disorganization of the splenic white pulp and the parasite load: (B) percentage of TIM-3+ cells, (C) TIM-3 cells/mm2, (E) percentage of CTLA-4+ cells, and (F) CTLA-4+ cells/mm2. Mann-Whitney test: (E) *p = 0.00160. Kruskal-Wallis test: (E) p = 0.021.

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