Figure 3
Schematic of the models and investigated hypotheses. Several biological hypotheses about metastatic dynamics were formalized as mathematical models and tested against the data. These included: same (A) or different (B) growth rates between primary and secondary tumors; only primary dissemination from the primary tumor or (C) secondary dissemination from brain metastases themselves; (D) possibility of a delay between cancer initiation and onset of metastatic ability; and (E) the possibility of a dormancy lag time between metastatic spread and growth initiation.
