Table 1 Results of diagnostic tests in pediatric patients with proven or probable invasive mold disease of the central nervous system.

From: Galactomannan and PCR in the Central Nervous System to Detect Invasive Mold Disease - A Retrospective Analysis in Immunocompromised Children

Pt #	Age/sex	Underl. diagnosis	Culture CNS	Micros. CNS	GM CNS	GM BAL	GM blood	PCR CNS	PCR BAL	PCR blood	Culture BAL	Pathol. BAL	Pathol. other sites	infection outside CNS	CNS infection
1	16.6 /m	ALL	negative^a	hyphae^a	n.d.	n.d.	7.5	A. fum.^a	n.d.	n.d.	n.d.	n.d.	hyphae^d	proven	proven^{g, h}
2	17.1/f	AML (HSCT)	n.d.	hyphae^a	n.d.	n.d.	0.5	A. fum.^a	n.d.	n.d.	n.d.	n.d.	hyphae^e	proven	proven^g
3	15.2/f	AML (HSCT)	n.d.	n.d.	n.d.	n.d.	n.d.	Fusarium spp^a	n.d.	Fusarium spp	n.d.	n.d.	n.d.	proven	probable^g
4	17.9 /m	ALL	negative^b	n.d.	2.7^b	3.0	2.0	n.d.	A. fum.	n.d.	negative	n.d.	n.d.	proven	probable^g
5	3.8/f	ALL	n.d.	hyphae^a	5.4^b	n.d.	negative	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	probable	proven^{g, h}
6	3.1 /m	SCI (HSCT)	n.d.	hyphae^a	n.d.	n.d.	5.2	negative^b	n.d.	n.d.	n.d.	hyphae	n.d.	proven	proven^h
7	17.7 /m	ALL (HSCT)	negative^b	hyphae^a	n.d.	n.d.	negative	negative^a	negative	n.d.	n.d.	hyphae	n.d.	proven	proven^g
8	3.8/f	ALL	n.d.	hyphae^a	negative^b	n.d.	0.8	A. fum.^a	n.d.	n.d.	n.d.	n.d.	hyphae^f	proven	proven^g
9	16.3 /m	ALL	n.d.	n.d.	n.d.	1.2	negative	A. fum.^b	n.d.	n.d.	A. fum.	n.d.	n.d.	proven	proven^{g, h}
10	10.6 /m	ALL	negative^b	n.d.	4.5^b	12.3	5.7	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	probable	probable^{g– i}
11	17.5 /m	CML (HSCT)	negative^b	n.d.	negative^b	2.0	negative	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	probable	probable^g
12	5.1/f	ALL	negative^c	hyphae^a	0.6^b	n.d.	negative	A. fum.^b	n.d.	n.d.	n.d.	n.d.	n.d.	possible	proven^{g, h}
13	16.9 /m	ALL	negative^b	n.d.	negative^b	9.8	0.6	n.d.	n.d.	n.d.	negative	n.d.	n.d.	probable	probable^g
14	5.7 /m	ALL	negative^b	n.d.	negative^b	7.3	negative	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	probable	probable ^{h, i}
15	18.0 /m	CGD (HSCT)	negative^b	n.d.	6.4^b	n.d.	2.5	n.d.	n.d.	n.d.	n.d.	hyphae	n.d.	proven	probable^{g, h}

Pt patient; f female; m male; ALL acute lymphoblastic leukemia, AML acute myeloid leukemia; HSCT hematopoietic stem cell transplantation; SCI severe immunodeficiency; CML chronic myeloid leukemia; CGD chronic granulomatous disease; CNS central nervous system; micros microscopy; n.d. not done; CSF cerebrospinal fluid; GM galactomannan; BAL broncho-alveolar lavage; A. fum. Aspergillus fumigatus.
Assay performed in ^abiopsy, ^bCSF, or ^cbiopsy and CSF
Pathological sites outside the CNS were ^dgut, ^eeye, and ^fappendix
Imaging findings were ^gfocal lesions, ^hhemorrhage/infarction, and ⁱmeningitis.

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Table 1 Results of diagnostic tests in pediatric patients with proven or probable invasive mold disease of the central nervous system.

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