Table 2 Antibiotic resistance phenotypes and resistance gene presence, aggregated based on genomic analysis of infecting bacteria.
Antibiotic | Non-ST131 (137 strains, set A) | ST131 (36 strains, set B) | SEA-C2 clone (16 strains, set C) | ST131, not SEA-C2 (20 strains, set D) | P value (A vs B) | P-value (C vs D) | P-value (A vs D) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Number | Percentage | Number | Percentage | Number | Percentage | Number | Percentage | ||||
Ampicillin | 89 | 65.0% | 29 | 80.56% | 15 | 93.75% | 14 | 70.00% | 0.107 | 0.104 | 0.803 |
Amoxicilin-clavulanate | 28 | 20.4% | 16 | 44.40% | 13 | 81.25% | 3 | 15.00% | 0.005* | 0.000* | 0.766 |
Piperacillin-tazobactam | 9 | 6.6% | 6 | 16.67% | 5 | 31.25% | 1 | 5.00% | 0.089 | 0.069 | 1.000 |
Cefazolin/Cefalexin | 48 | 35.0% | 22 | 61.11% | 13 | 81.25% | 9 | 45.00% | 0.007* | 0.041* | 0.457 |
Ceftriaxone | 29 | 21.2% | 21 | 58.33% | 13 | 81.25% | 8 | 40.00% | 0.000* | 0.019* | 0.088 |
Ceftazidime | 24 | 17.5% | 18 | 50.00% | 11 | 68.75% | 7 | 35.00% | 0.000* | 0.078 | 0.077 |
Cefepime | 22 | 16.1% | 20 | 55.56% | 12 | 75.00% | 8 | 40.00% | 0.000* | 0.049* | 0.028* |
Imipenem | 1 | 0.7% | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% | 1.000 | 1.000 | 1.000 |
Meropenem | 1 | 0.7% | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% | 1.000 | 1.000 | 1.000 |
Ertapenem | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% | 0.000* | 1.000 | 1.000 |
Gentamicin | 17 | 12.4% | 15 | 41.67% | 11 | 68.75% | 4 | 20.00% | 0.000* | 0.006* | 0.313 |
Amikacin | 4 | 2.9% | 4 | 11.11% | 4 | 25.00% | 0 | 0.00% | 0.059 | 0.031* | 1.000 |
Ciprofloxacin | 34 | 24.8% | 25 | 69.44% | 15 | 93.75% | 10 | 50.00% | 0.000* | 0.009* | 0.031* |
Co-trimoxazole | 61 | 44.5% | 20 | 55.6% | 12 | 75.00% | 8 | 40.00% | 0.264 | 0.049* | 0.811 |
Broad-spectrum cephalosporins | 30 | 21.9% | 21 | 58.3% | 13 | 81.25% | 8 | 40.00% | 0.000* | 0.019* | 0.095 |
MDR resistance | 48 | 35.0% | 24 | 66.7% | 14 | 87.50% | 10 | 50.00% | 0.000* | 0.032* | 0.220 |
Resistance Gene | |||||||||||
CTX-M-15 | 4 | 2.92% | 14 | 38.89% | 12 | 75.00% | 2 | 10.00% | 0.000* | 0.000* | 0.169 |
Other CTX-M | 14 | 10.22% | 6 | 16.67% | 0 | 0.00% | 6 | 30.00% | 0.377 | 0.024* | 0.024* |
OXA-1 | 8 | 5.84% | 14 | 38.89% | 14 | 87.50% | 0 | 0.00% | 0.000* | 0.000* | 0.393 |
OXA-48 | 1 | 0.73% | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% | 1.000 | 1.000 | 1.000 |
TEM-1D | 71 | 51.82% | 11 | 30.56% | 0 | 0.00% | 11 | 55.00% | 0.000* | 0.001* | 0.816 |
Other beta-lactamase^ | 9 | 6.57% | 2 | 5.56% | 1 | 6.25% | 1 | 5.00% | 1.000 | 1.000 | 1.000 |
