Figure 8 | Scientific Reports

Figure 8

From: A FAM83A Positive Feed-back Loop Drives Survival and Tumorigenicity of Pancreatic Ductal Adenocarcinomas

Figure 8

Elevated FAM83A expression in pancreatic cancers is driven by a MEK/ERK-JUNB-driven feed-forward signalling loop. The oncogene FAM83A promotes activation of pro-survival MEK-ERK signalling pathway that regulates transcription of JUNB which feeds forward to maintain elevated expression of FAM83A in turn promoting pancreatic cancer growth, survival and tumorigenicity. Disruption of the MEK-FAM83A positive loop will serve as a tumour-specific therapeutic target in KRAS-dependent and independent pancreatic cancers.

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