Figure 2

Normalized indication rank for all indications: Percentage of psychoactives in the Top10 (a), Top25 (b), Top40 (c), and Top100 (d) ranked predictions for mental health indications. The shading of the bars indicates the number of compounds known to treat an indication in the ranked lists. The green line shows the results of randomizing the predicted compounds and the straight-line segment indicates the mean of the randomized distribution. A one-tailed Kolmogorov-Smirnov test is performed to show that these distributions are statistically different than the randomized distributions (p < 0.001) Raw KS-p-values are presented in Table S10. The data indicate that the prediction of psychoactives by the CANDO platform for mental health indications is not due to chance and that a significant fraction of mental health indications is much more likely to be amenable to treatment by them or an analogously behaving compound (left-hand side of the graphs above the green control line). The circled indications are Seasonal Affective Disorder, Circadian Rhythm Sleep Disorders, and Jet Lag Syndrome.