Figure 3
Normalized compound rank for all psychoactives: Percentages of mental health indications predicted to be treated by psychoactives for the Top10 (a), Top25 (b), Top40 (c), and Top100 (d) ranked predictions. Bars shown in red indicate non-randomized results, bars in green indicate the same results after the compounds in the ranked lists have been randomized, and bars in blue show the percentages after (only) the indications have been randomized in the ranked lists. The green line segment indicates the mean of the randomized psychoactive distribution and the blue line segment indicates the mean of the randomized indication distribution. A one-tailed Kolmogorov-Smirnov test for the normal (red) distribution against the randomized (green) one shows statistical significance (p < 0.000001) for each of the panels above. Raw KS p-values are presented in Table S10. In addition, raw T-test p-values are given in Table S11. The data indicate that the psychoactive compounds select mental health indications within their top rankings at a much higher likelihood than compounds selected at random.
