Table 1 Distribution of clinical variables according to HPV integration patterns in the GWAS set.
| Â | Total | group A | group B | group C | p-value | |
|---|---|---|---|---|---|---|
(N = 161) | (N = 38) | (N = 111) | (N = 12) | |||
Stage group | ||||||
|  | ~IIB | 143 | 36 (94.74) | 96 (86.49) | 11 (91.67) | 0.449‡ |
III/IVA | 18 | 2 (5.26) | 15 (13.51) | 1 (8.33) | ||
Histologic grade | ||||||
(miss = 5) | well/moderate | 118 | 30 (81.08) | 78 (72.9) | 10 (83.33) | 0.492†|
poor | 38 | 7 (18.92) | 29 (27.1) | 2 (16.67) | ||
Histologic type | ||||||
|  | SCC | 142 | 34 (89.47) | 96 (86.49) | 12 (100) | 0.510‡ |
AD/ASC | 19 | 4 (10.53) | 15 (13.51) | 0 (0.00) | ||
Tumor size | ||||||
|  | <4 cm | 71 | 23 (60.53) | 46 (41.44) | 2 (16.67) | 0.017†|
≥4 cm | 90 | 15 (39.47) | 65 (58.56) | 10 (83.33) | ||
Smoking | ||||||
|  | non-smoker | 131 | 31 (81.58) | 90 (81.08) | 10 (83.33) | 0.981†|
present/ex-smoker | 30 | 7 (18.42) | 21 (18.92) | 2 (16.67) | ||
HPV type | ||||||
(miss = 18) | 16 | 113 | 33 (91.67) | 71 (73.96) | 9 (81.82) | 0.115‡ |
18 | 21 | 1 (2.78) | 18 (18.75) | 2 (18.18) | ||
58 | 9 | 2 (5.56) | 7 (7.29) | 0 (0.00) | ||
Nodal status | ||||||
|  | Node = 0 | 69 | 20 (52.63) | 45 (40.54) | 4 (33.33) | 0.338†|
1 ≤ node ≤ 5 | 92 | 18 (47.37) | 66 (59.46) | 8 (66.67) | ||
Age (yr) | mean ± std | 161 | 58.89 ± 12.45 | 54.25 ± 14.13 | 60.75 ± 12.44 | 0.090* |
median (range) | 161 | 59.5 (34–79) | 54 (27–83) | 58.5 (39–77) | ||
