Figure 2
From: Serum developmental endothelial locus-1 is associated with severity of sepsis in animals and humans
Sections of lung from CLP and control mice stained for heparan sulfate, Del-1, and glycocalyx. Scale bars, 50 μm. (A) The endothelial glycocalyx was mostly intact, and heparan sulfate and Del-1 were spatially distributed in the endothelial cell and extracellular matrix. (B) After 24 h of CLP, the endothelial glycocalyx was almost completely degraded with less formation of heparan sulfate and Del-1. CLP: cecal ligation and puncture; Del-1: developmental endothelial locus-1; HS: heparan sulfate.
