Figure 7 | Scientific Reports

Figure 7

From: Down-regulation of cyclin-dependent kinase 5 attenuates p53-dependent apoptosis of hippocampal CA1 pyramidal neurons following transient cerebral ischemia

Figure 7

Effect of roscovitine and IPC on apoptosis of CA1 pyramidal neuroins using TUNEL staining in the TCI (left column), roscovitine + TCI (middle column), and IPC + TCI (right column) groups at sham and 5 days after TCI. Many TUNEL+ CA1 pyramidal neurons (arrows) are found in the stratum pyramidale (SP) of the TCI group 5 days after TCI. However, TUNEL+ cells are significantly low in the roscovitine + TCI and IPC + TCI groups compared with the TCI group, respectively. SO, stratum oriens; SR, stratum radiatum. Scale bar = 50 µm. The quantitative graph is shown the percentage of TUNEL+ cells in the SP. The bars are reported as means ± SEM from three independent experiments (n = 7, *P < 0.05 vs. sham group; #P < 0.05 vs TCI group; †P < 0.05 vs roscovitine + TCI group).

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