Figure 6

Synthesis of compounds 17a-b. Reagents and conditions: (a) NaCN, molecular sieves, DMF, 60 °C, 48 h, 67% for 16a, 44% for 16b. (b) NH2OH, KOH, MeOH, 0 °C, 3 h, 50% for 17a, 34% for 17b.

Synthesis of compounds 17a-b. Reagents and conditions: (a) NaCN, molecular sieves, DMF, 60 °C, 48 h, 67% for 16a, 44% for 16b. (b) NH2OH, KOH, MeOH, 0 °C, 3 h, 50% for 17a, 34% for 17b.