Table 1 Anti-proliferative effect of compounds on SH-SY5Y cellsa.

From: Design, synthesis and biological evaluation of a series of CNS penetrant HDAC inhibitors structurally derived from amyloid-β probes

Compound

SH-SY5Y (GI50; μM)

Compound

SH-SY5Y (GI50; μM)

5

60 ± 1.5

13

>100

6a

58.3 ± 10.8

14a

>100

6b

38.1 ± 0.2

14b

28.2 ± 0.75

6c

54.7 ± 0.95

14c

34.6 ± 0.6

6d

26.8 ± 1.35

14d

20.7 ± 1.0

9a

25.7 ± 0.05

17a

17.5 ± 0.35

9b

2.01 ± 0.33

17b

21.4 ± 1.65

SAHA

2.90 ± 0.28

  
  1. aCytotoxicity on SH-SY5Y neuroblastoma cell line (72 h). Data are expressed as the mean ± SD (n = 4).
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