Figure 1 | Scientific Reports

Figure 1

From: A high throughput multi-locus insecticide resistance marker panel for tracking resistance emergence and spread in Anopheles gambiae

Figure 1

Raw intensities from the iPLEX MassARRAY assays in Ghana show multiple clusters among heterozygote samples (orange points) for Gste2-114T (a) and Ace1-280S (b). This is typically seen when duplications create ratios of mutant/wild-type alleles that differ from the usual 1/1 in heterozygotes. In comparison, equivalent data for Vgsc-995F (c) shows the normal pattern, with heterozygotes consistently falling in a single cluster along a straight diagonal line. Homozygote wild-type and homozygote mutant samples are shown in blue and green respectively. Colour-coding the Gste2-114T data according to whether samples carry Dup7 (red) or not (black) shows that heterozygotes with no duplication predominantly fall along a straight diagonal line (d). The X and Y axes respectively show intensities for the wild-type and mutant alleles.

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