Figure 1 | Scientific Reports

Figure 1

From: Rhinovirus-induced IFNβ expression is NFκB-dependent and regulated by the macrophage microenvironment

Figure 1

Bone marrow-derived murine macrophages differentiated with GM-CSF have reduced expression of IFNβ upon RV infection and a trend towards a higher expression of viral load. Bone marrow-derived murine monocytes were differentiated to macrophages by stimulation with either GM-CSF or M-CSF followed by infection with RV1B for 24 h. Gene expression of IFNβ (A) and vRNA (B) was measured by real-time PCR and data is presented as mean ± standard deviation fold change of untreated M-CSF stimulated macrophages relative to HPRT expression. Comparison of different groups was performed by Kruskal-Wallis with Wilcoxon post-testing. *p < 0.05, **p < 0.01. ***p < 0.001 vs. own CTRL if not stated otherwise. Data from 6 independent experiments.

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