Figure 1
From: Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β
Frequency and distribution of ILC subsets in the peripheral blood of healthy volunteers. (A) Gating strategy for total ILCs ((CD45+ Lin-CD127+), ILC1s (CD45+ Lin-CD127+ cKit-NKp44-), ILC2s (CD45+ Lin-CD127+ CRTH2+) and ILC3s (CD45+ Lin-CD127+ cKit+ NKp44−/+). Panels are representative of multiple independent experiments (n = 89). (B) The frequency of total ILCs per million CD45+ cells and (C) the percentage of total ILCs per million CD45+ cells. Each dot represents an individual donor (n = 89) and the horizontal lines are the GM. ILC surface markers were used to quantify (D) the frequency of ILC1 (blue dots), ILC2 (orange dots) and ILC3 (gray dots) per million CD45+ cells and (E) the percentage of ILC subsets per total ILC cells in 69 donors. (F) ILC3a (CD45+ Lin-CD127+ cKit + NKp44-) and ILC3b (CD45+ Lin-CD127+ cKit+ NKp44+) frequencies per million lymphocytes in the peripheral blood. (G) Stacked bars individual ILC subsets by individual donor (n = 69).
