Figure 2
From: Sensory sensitivity as a link between concussive traumatic brain injury and PTSD
Lateral fluid percussion injury reduces tone fear memory. (A) Experimental design. (B,C) FPI (fluid percussion injury) rats displayed slightly elevated levels of freezing behavior during pre-exposure to pure tone (2800 Hz/75 dB) trials (B) and during inter stimuli intervals (C). (D) FPI had no effect on baseline freezing prior to the first tone-shock conditioning trial. Although both groups learned, FPI had no effect on freezing across acquisition trials when pure tones were paired with mild footshocks. (E) While both groups decreased freezing across context extinction sessions, FPI had no effect on fear to the conditioning context. (F) FPI rats froze less during tone CS trials when presented in a novel context. *p < 0.05 vs. Sham. Data are represented as mean ± SEM.
