Figure 3 | Scientific Reports

Figure 3

From: The human long non-coding RNA gene RMRP has pleiotropic effects and regulates cell-cycle progression at G2

Figure 3

Schematic of key CDK complexes and RMRP function during the cell cycle. CHH fibroblasts delay in G2 phase. Although effects are pleiotropic and affect many cell cycle regulators, the main Cyclin-CDK complexes driving progression through G2 phase show differential regulation in CHH cells. First, mRNA levels of CDK2 that stimulates Cyclin A/B-CDK1 activation at the S/G2 border are reduced. Second, CHH cells show reduced mRNA levels of direct and indirect regulators of CDK1 activity, as Cdc25C and MAST-L.

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