Table 2 Average relative abundances of main microbial groups (phylum, family, genus).

From: Diversity of vaginal microbiome and metabolome during genital infections

Level

 

Group

Relative abundance

P-value

HC (%)

CT (%)

VVC (%)

BV (%)

Overalla

CT vs. HCb

VVC vs. HCb

BV vs. HCb

Phylum

Firmicutes

92.41

89.78

79.22

60.61

<0.001

0.004

<0.001

Actinobacteria

3.39

5.62

12.02

18.38

<0.001

<0.001

<0.001

Bacteroidetes

2.71

2.99

5.02

11.51

<0.001

0.019

<0.001

Fusobacteria

0.22

0.42

0.54

7.87

0.003

<0.001

Proteobacteria

0.57

0.60

2.23

0.41

0.030

0.013

Family

Lactobacillaceae

79.19

67.50

56.75

18.83

<0.001

0.004

<0.001

Lachnospiraceae

3.16

8.10

6.61

13.67

0.003

<0.001

0.007

0.007

Bifidobacteriaceae

2.93

4.17

9.56

11.82

<0.001

0.044

<0.001

<0.001

=

Ruminococcaceae

5.22

6.59

6.29

6.21

Veillonellaceae

0.74

3.72

2.42

10.91

<0.001

0.031

0.004

<0.001

Prevotellaceae

1.16

1.60

3.76

9.15

<0.001

0.002

<0.001

Coriobacteriaceae

0.32

1.30

2.29

5.96

<0.001

0.031

<0.001

<0.001

Leptotrichiaceae

0.20

0.41

0.53

7.77

0.002

<0.001

=

Uncl. Clostridiales

1.66

1.56

1.44

1.58

Tissierellaceae

1.14

0.29

1.23

3.04

<0.001

0.044

<0.001

Aerococcaceae

0.03

0.24

1.51

2.07

<0.001

0.034

<0.001

Clostridiaceae

0.19

0.69

0.36

2.17

<0.001

0.009

<0.001

=

Bacteroidaceae

0.69

0.91

0.81

0.86

=

Streptococcaceae

0.42

0.50

1.05

0.55

=

Pasteurellaceae

0.03

0.10

1.46

0.02

=

Porphyromonadaceae

0.38

0.13

0.09

0.83

Gemellaceae

0.06

0.06

0.82

0.28

0.012

0.013

0.005

Actinomycetaceae

0.06

0.09

0.10

0.53

0.010

0.029

0.006

Peptostreptococcaceae

0.04

0.01

0.08

0.64

0.011

0.017

0.002

Genus

Lactobacillus

79.16

67.45

56.69

18.80

<0.001

0.004

<0.001

Gardnerella

2.72

3.65

7.68

11.44

<0.001

0.003

<0.001

Prevotella

1.16

1.60

3.76

9.15

<0.001

0.002

<0.001

Megasphaera

0.06

2.97

1.04

8.64

<0.001

0.001

0.036

<0.001

Roseburia

1.09

4.42

3.51

3.51

<0.001

<0.001

<0.001

0.031

Sneathia

0.18

0.41

0.53

7.76

<0.001

0.020

<0.001

=

Shuttleworthia

0.03

0.54

0.31

7.48

Faecalibacterium

1.49

2.31

2.14

2.09

0.027

0.003

0.041

Atopobium

0.17

1.00

1.94

4.92

<0.001

0.024

0.001

<0.001

Ruminococcaceae (other)

1.35

1.95

1.86

1.81

0.023

0.003

0.041

=

Uncl. Clostridiales

1.66

1.56

1.44

1.58

=

Uncl. Ruminococcaceae

1.08

1.03

1.02

1.03

Aerococcus

0.03

0.24

1.50

2.06

<0.001

0.021

<0.001

Dialister

0.37

0.56

0.78

2.02

<0.001

0.011

<0.001

<0.001

Clostridium

0.16

0.65

0.32

2.14

<0.001

0.008

<0.001

Bacteroides

0.69

0.91

0.81

0.86

Blautia

0.35

0.91

0.77

0.74

<0.001

<0.001

0.004

=

Coprococcus

0.61

0.66

0.63

0.59

Streptococcus

0.40

0.49

1.04

0.54

0.045

0.012

0.013

=

Oscillospira

0.65

0.56

0.53

0.58

Ruminococcus

0.54

0.58

0.59

0.56

Bifidobacterium

0.20

0.46

1.28

0.33

<0.001

<0.001

0.005

Uncl. Lachnospiraceae

0.40

0.59

0.54

0.52

0.029

0.006

=

Parvimonas

0.20

0.07

0.17

1.39

<0.001

<0.001

=

Peptoniphilus

0.35

0.15

0.13

1.09

=

Haemophilus

0.02

0.10

1.42

0.02

Uncl. Coriobacteriaceae

0.10

0.19

0.24

0.89

<0.001

0.023

0.017

<0.001

=

Akkermansia

0.30

0.39

0.35

0.32

=

Anaerococcus

0.48

0.03

0.46

0.39

Escherichia

0.13

0.33

0.40

0.23

<0.001

<0.001

<0.001

=

Porphyromonas

0.25

0.05

0.01

0.73

Ureaplasma

0.25

0.04

0.41

0.09

<0.001

0.001

0.005

Genus

Peptostreptococcus

0.03

<0.01

0.08

0.63

0.018

0.024

0.009

Finegoldia

0.09

0.03

0.45

0.16

0.016

0.015

Veillonella

0.08

0.07

0.46

0.08

0.038

0.019

Gemella

0.05

0.03

0.32

0.27

<0.001

<0.001

Mobiluncus

0.03

0.08

0.02

0.49

0.013

0.002

Alloscardovia

<0.01

0.06

0.57

<0.01

0.002

0.041

<0.001

Uncl. Gemellaceae

0.01

0.03

0.49

<0.01

0.019

0.041

=

Uncl. Rs-045

<0.01

<0.01

0.04

0.43

  1. For each taxa, significant p-values of the non-parametric Kruskal-Wallis test and of pairwise comparison (Dunn’s test) of women affected by Chlamydia trachomatis infection (CT), vulvo-vaginal candidiasis (VVC) or bacterial vaginosis (BV) versus healthy women (HC) are reported. Arrows indicate the direction of the variation with respect to HC: ↓, decreased; ↑, increased; =, unchanged.
  2. aP-value of the Kruskal-wallis test for equal medians among groups.
  3. bP-value of the Dunn’s post-hoc test test for equal medians between each pathological condition (i.e.: CT, VVC or BV) and HC.