Figure 6
From: Synergy between B cell receptor/antigen uptake and MHCII peptide editing relies on HLA-DO tuning
The molecular and cellular impact of fine-tuning DM/DO stoichiometry. (a–d) Mathematical and catalytic meaning of DMfree/CLIPfreq illustrated by alternative presentation of data shown in Figs 1d, 3c, 4c and 5g, respectively. Each dot represents an individual cell analyzed by iFACS. Single cells from distinct groups are differentiated by colors, as indicated. The slope of a line connecting the origin with each dot equals to DMfree/CLIPfreq in the cell. The line with shaded range indicates mean ± SEM of DMfree/CLIPfreq for the group of cells using the same color-code. (e) Two synchronized affinity checkpoints for antigen presentation in B cells. Ligands with different binding affinities or proteins at different levels per cell are indicated using different degrees of color intensity.
