Table 2 Molecular Signatures Database (MSigDB) GO Ontology pathways enriched for hippocampal volume.
Pathways | # of genes/set size | Corrected p-value |
|---|---|---|
Oxidoreductase Activity Acting On Sulfur Group Of Donors | 10/10 | 4.68 × 10−4 |
Neuron differentiation | 73/76 | 0.001181 |
Cell Projection | 105/108 | 0.001181 |
Microvillus | 11/11 | 0.001479 |
Neurite Development | 51/53 | 0.00312 |
Cell Recognition | 18/19 | 0.00312 |
Generation of Neurons | 80/83 | 0.00312 |
Transmembrane Receptor Protein Kinase Activity | 50/51 | 0.00312 |
Protein Domain Specific Binding | 71/72 | 0.00312 |
Neuron Development | 59/61 | 0.003242 |
Axonogenesis | 41/43 | 0.003242 |
Cellular Morphogenesis During Differentiation | 47/49 | 0.004265 |
Neurogenesis | 90/93 | 0.005646 |
Transmembrane Receptor Protein Tyrosine Kinase Activity | 42/43 | 0.005903 |
Vesicle Mediated Transport | 188/194 | 0.011803 |
Glutamate Receptor Activity | 20/20 | 0.011803 |
Cytoskeletal Protein Binding | 153/159 | 0.011803 |
Jnk Cascade | 45/47 | 0.011925 |
Stress Activated Protein Kinase Signaling Pathway | 47/49 | 0.013007 |
Metabotropic Glutamategaba B Like Receptor Activity | 10/10 | 0.01599 |
Phagocytosis | 16/17 | 0.018307 |
Regulation of Axonogenesis | 10/10 | 0.018307 |
Regulation of Anatomical Structure Morphogenesis | 24/25 | 0.018307 |
Perinuclear Region of Cytoplasm | 51/54 | 0.018746 |
Glutamate Signaling Pathway | 16/17 | 0.021249 |
Cornified Envelope | 12/13 | 0.023212 |
Lipoprotein Binding | 18/18 | 0.024574 |
Pdz domain Binding | 14/14 | 0.025352 |
Protein Tyrosine Kinase Activity | 62/63 | 0.026949 |
3 5 Cyclic Nucleotide Phosphodiesterase Activity | 13/13 | 0.026949 |
Negative Regulation of Cell Proliferation | 148/156 | 0.02873 |
Protein Oligomerization | 35/40 | 0.02873 |
Exopeptidase Activity | 29/32 | 0.02873 |
Extracellular Matrix | 95/100 | 0.030238 |
Cell Cell Adhesion | 83/86 | 0.030238 |
Proteinaceous Extracellular Matrix | 93/98 | 0.030238 |
Maintenance of Protein Localization | 12/13 | 0.030238 |
Maintenance Of Cellular Protein Localization | 11/11 | 0.030238 |
Transmembrane Receptor Protein Phosphatase Activity | 19/19 | 0.030238 |
Cell Projection Biogenesis | 23/25 | 0.030415 |
Cyclic Nucleotide Phosphodiesterase Activity | 14/14 | 0.030799 |
Central Nervous System Development | 110/123 | 0.030799 |
Protein Tyrosine Phosphatase Activity | 52/53 | 0.031472 |
Active Transmembrane Transporter Activity | 113/122 | 0.041004 |
