Table 1 Table of standard, fixed simulation parameters, and the free parameters that can be optimized (last seven rows).
Symbol | Value | Unit | Description |
|---|---|---|---|
L sys | 1000 | μm | Linear system size |
Δtsim | 1 | min | Simulation time step |
T sim | 100 | min | Total simulation time per run |
N runs | 10000 | — | Number of runs per parameter set |
D | 6000 | μm2/min | Diffusion constant of chemo-attractant |
k | 0.6 | 1/min | Decay rate of chemo-attractant (CA) |
N tar | 10 | — | Initial number of target cells |
r tar | 10 | μm | Radius of target cells |
v tar | [0, 6] | μm/min | Speed of target cells, uniformly distributed |
ε tar | [0, 1] | — | Persistence of target cells, uniformly distributed |
N imm | 1 | — | Number of immune cells |
r imm | 10 | μm | Radius of immune cell |
v N | [0, 6] | μm/min | Speed of immune cell in normal mode |
v A | [0, 6] | μm/min | Speed of immune cell in approach mode |
ε N | [0, 1] | — | Persistence of immune cell in normal mode |
ε A | [0, 1] | — | Persistence of immune cell in approach mode |
c A0 | [−5, 5] | — | Bias of immune cell for approach mode |
c A1 | [−500, 500] | — | Sensitivity of immune cell for temporal CA differences |
c R1 | [−500, 500] | — | Sensitivity of immune cell for spatial CA differences |
