Table 2 Incidences and hazard ratios for risks of PE, PAOD, and DVT in recipients of various ADT treatment for prostate cancer.

From: Associations between Peripheral Thromboembolic Vascular Disease and Androgen Deprivation Therapy in Asian Prostate Cancer Patients

 

Event no

Person-years

Rate (per 1000 person-years)

Adjusted HR (95% CI)a

Outcome: DVT

Control

37

22811

1.62

Ref.

ADT overall

92

32021

2.87

2.11 (1.33–3.36)**

   Surgical castration

2

1219

1.64

0.96 (0.23–4.02)

   Anti-androgen

51

18209

2.80

2.17 (1.30–3.62)**

   Chemical castration

39

12592

3.10

2.27 (1.32–3.89)**

     GnRH agonist alone

4

2504

1.60

1.30 (0.45–3.77)

     CAB

35

10089

3.47

2.53 (1.45–4.42)**

   Total castration

41

13811

2.97

2.06 (1.23–3.46)**

Duration of chemical castration

     ≤180 days

5

1152

4.34

2.78 (1.00–7.72)*

     181–720 days

17

5882

2.89

2.16 (1.12–4.17)*

     >720 days

17

5558

3.06

2.29 (1.17–4.50)*

     ≤720 days

22

7034

3.13

2.28 (1.24–4.19)**

     >720

17

5558

3.06

2.31 (1.17–4.53)*

Outcome: PE

Control

12

22896

0.52

Ref.

ADT overall

32

32158

1.00

2.10 (0.94–4.72)

   Surgical castration

0

1230

0.00

NA

   Anti-androgen

18

18295

0.98

2.25 (0.91–5.60)

     Chemical castration

14

12634

1.11

2.51 (0.97–6.46)

       GnRH agonist alone

0

2515

0.00

NA

      CAB

14

10119

1.38

3.11 (1.19–8.16)*

   Total castration

14

13863

1.01

2.07 (0.85–5.05)

Duration of chemical castration

   ≤180 days

1

1155

0.87

2.59 (0.30–22.2)

   181–720 days

7

5902

1.19

3.27 (1.09–9.76)*

   >720 days

6

5576

1.08

1.95 (0.61–6.22)

   ≤720 days

8

7058

1.13

3.16 (1.10–9.07)*

   >720

6

5576

1.08

1.95 (0.61–6.19)

Outcome: PAOD

Control

16

22887

0.70

Ref.

ADT overall

33

32103

1.03

1.01 (0.53–1.92)

   Surgical castration

0

1230

0.00

NA

   Anti-androgen

22

18267

1.20

1.17 (0.59–2.34)

   Chemical castration

11

12606

0.87

0.84 (0.38–1.89)

      GnRH agonist alone

0

2515

0.00

NA

      CAB

11

10092

1.09

1.01 (0.45–2.30)

      Total castration

11

13836

0.80

0.78 (0.35–1.75)

Duration of chemical castration

   ≤180 days

1

1154

0.87

1.26 (0.15–10.3)

   181–720 days

4

5894

0.68

0.71 (0.23–2.21)

   >720 days

6

5558

1.08

0.91 (0.34–2.48)

   ≤720 days

5

7049

0.71

0.78 (0.27–2.21)

   >720

6

5558

1.08

0.92 (0.34–2.49)

  1. *p < 0.05; **p < 0.01.
  2. aAdjusted for all variables listed in Table 1.