Figure 8
From: Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
Stimulation of ER-β by estradiol contributes to FATP1/SLC27A1 expression and cell survival of breast cancer cells (BCCs). FATP1, whose expression may be controlled by estradiol via ER-β that is a pro-survival element, mediating the transport of Fatty acids (FA), which are essential for BCCs (A). BCCs exposed to PHTPP (ER-β antagonist) show a decreased cell viability and lower uptake of FA suggesting that ER-β controls FATP1/SLC27A1 expression (B). The inhibition of FATP1 with arylpiperazine 5k (DS22420314) interferes with the uptake of FA and cell viability indicating that FATP1 is a putative therapeutic target in BC (C).
