Figure 2 | Scientific Reports

Figure 2

From: Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice

Figure 2

Cardiac remodeling, fibrosis, and related hormone and gene expression changes in SCT−/− mice. (A) The gross morphology, H&E and Picrosirius Red Collagen staining of the hearts. The whitish fibrous tissue and deformed RV contour can be seen in the gross morphology of the heart of SCT−/− mouse. The dilated RA with hypertrophic wall and fibrosis and hypertrophy mixed RV wall can be seen in the longitudinal section of the heart of SCT−/− mouse. The deformed and dilated RV contour can be seen in the cross-sectional view of the heart of SCT−/− mouse. In the picrosirius staining, the fibrous tissues can be seen as deep red fibers under bright field. (B) Increased cardiac aldosterone level and VEGF in SCT−/− mice (n = 8/group; *p < 0.05, **p < 0.01). The gene transcript levels in the heart of SCT−/− mice compared with C57BL/6N mice with internal control: GAPDH expression; 6-month-old mice; n = 6–7; *p < 0.05; **p < 0.01; ***p < 0.001 (n = 6/group for staining).

Back to article page