Figure 1

Weight losses associated with DSS-induced colitis in Tmem17^Gt and wild-type mice. (a) Weight losses were exacerbated in the DSS mice that were co-treated with the murine STING agonist, DMXAA, and attenuated in the Tmem173^Gt group of mice. To examine the effects of a given treatment regime on weight change, we isolated groups and compared the effects of (b) DSS-induced colitis either alone or following co-treatments with (c) 5 mg/kg or (d)10 mg/kg of DMXAA (i.p.). Statistical significance between data sets was assessed by one-way ANOVA followed by Tukey’s multiple comparisons post-hoc test between all groups. Values are means ± SEM, n ≥ 8 mice per group with differences denoted by *P < 0.05,**P < 0.01, ***P < 0.001 relative to DSS-treated WT.