Figure 2
Oxo effect on pro-and anti-inflammatory cytokines protein levels in the hippocampus. ELISA analysis of IL-1β (A) and IL-6 (B) protein levels at different time-points (24 h, 48 h and 72 h) after acute Oxo treatment revealed a significant decrease at 48 h and 72 h as compared to control group (Ctrl). Scopolamine (Scop), injected 20 min before acute Oxo treatment, completely blocked Oxo effect. Scopolamine alone did not show significant changes of both IL-1β and IL-6. The ELISA analysis of IL-10 (C) and TGF-β1 (D) protein levels did not show significant variation in all experimental groups. Data are reported as means ± SE. PLSD: **P < 0.01, ****P < 0.0001.
