Figure 5
Pro-inflammatory and anti-inflammatory cytokine levels, including NF-κB-p65, in the hippocampus of rats exposed to CRS and their regulation by chronic Oxo treatment. ELISA analysis of IL-1β (A) and IL-6 (B) protein levels revealed a significant increase in CRS group. The chronic Oxo treatment completely blocked CRS effect on IL-1β and IL-6. Oxo treated group did not show significant changes of both IL-1β and IL-6. The ELISA analysis of IL-10 (C) and TGF-β1 (D) protein levels did not show significant variation in all experimental groups. (E) Cropped band-images of representative Western blot results. The analysis of NF-κB-p65 protein levels did not show significant changes in all experimental groups. Full-length band-lines are presented in Supplementary Fig. S3. Ctrl, Control group. Data are reported as means ± SE. t-test: *P < 0.05, ***P < 0.001.
