Figure 9

Degeneration of various retinal cell types in Ppt1 ko mice. The number of rows of photoreceptor nuclei (a) and the density of PNA-labeled cone photoreceptor cells (b), BRN-3A-positive retinal ganglion cells in retinal sections (c) or retinal flatmounts (d), PKCα-positive rod bipolar cells (e) and SCGN-positive cone bipolar cells (f) were determined in 45-, 112- and 240-day-old Ppt1 ko (filled bars) and wild-type mice (open bars). Each bar represents the mean value ± SEM of six animals. Statistical analyses of data were performed with the two-way ANOVA followed by a Bonferroni post-hoc test (a–c,e,f) or the Mann-Whitney U test (d). n.s.: not significant; *p < 0.05; **p < 0.01; ***p < 0.001.