Table 1 Clinical characteristics of NSCLC patients in overall INT cohort and by expression of TLR3 on tumor cells (TLR3-t), stromal immune infiltrate (TLR3-s), and tumor-infiltrating immune cells (TLR3-i).

From: Toll-like receptor 3 as a new marker to detect high risk early stage Non-Small-Cell Lung Cancer patients

 

Overall cohort

TLR3-t posa

TLR3-t neg

P valueb

TLR3-s posc

TLR3-s neg

P valuea

TLR3-i posd

TLR3-i neg

P valuea

(N = 194)

(N = 73)

(N = 121)

(N = 110)

(N = 84)

(N = 113)

(N = 81)

Histology

Adeno-carcinoma

117 (60%)

39 (53%)

78 (64%)

0.1279

58 (53%)

59 (70%)

0.0135

61 (54%)

56 (69%)

0.0334

others

77 (40%)

34 (47%)

43 (36%)

52 (47%)

25 (30%)

52 (45%)

25 (31%)

pT

1, 1a, 1b

112 (58%)

48 (66%)

64 (53%)

0.079

56 (51%)

56 (67%)

0.0277

60 (53%)

52 (64%)

0.1227

2, 2a

82 (42%)

25 (34%)

57 (47%)

54 (49%)

28 (33%)

53 (47%)

29 (36%)

Age

<60

40 (21%)

13 (18%)

27 (22%)

0.4523

26 (24%)

14 (17%)

0.2345

28 (25%)

12 (15%)

0.0907

≥60

154 (79%)

60 (82%)

94 (78%)

84 (76%)

70 (83%)

85 (75%)

69 (85%)

BMI

<25

100 (52%)

31 (42%)

69 (57%)

0.0493

58 (53%)

42 (50%)

0.7065

58 (51%)

42 (52%)

0.9425

≥25

94 (48%)

42 (58%)

52 (43%)

52 (47%)

42 (50%)

55 (49%)

39 (48%)

Gender

Male

143 (74%)

49 (67%)

94 (78%)

0.1054

83 (75%)

60 (71%)

0.5279

81 (72%)

62 (77%)

0.4481

Female

51 (26%)

24 (33%)

27 (22%)

27 (25%)

24 (29%)

32 (20%)

19 (23%)

Smoker

Yes

172 (89%)

62 (85%)

110 (91%)

0.2034

99 (90%)

73 (87%)

0.5005

102 (90%)

70 (86%)

0.4048

Never

22 (11%)

11 (15%)

11 (9%)

11 (10%)

11 (13%)

11 (10%)

11 (14%)

  1. The relationships between categorical variables were examined by chi-square test. Two-sided P values that were below the conventional 5% threshold were considered to be statistically significant. Analyses were conducted using SAS (SAS 9.4 Institute Inc., Cary, NC, USA).
  2. aScore of TLR3-t expression: percentage of positive tumor cells ≥3.
  3. bChi-square test.
  4. cScore of TLR3-s expression: percentage of positive immune cells ≥1.
  5. dScore of TLR3-i expression: percentage of positive immune cells ≥1.
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