Figure 6
Higher level expression of plectin is associated with poor patient survival in lung adenocarcinoma patients and non-smokers, while opposite observation is on lung squamous carcinoma, and plectin isoforms 1a and 1f are highly expressed in NSCLC patients. (A–C) Kaplan–Meier survival plot of NSCLC patients32. (A) Lung adenocarcinoma, (B) non-smokers in NSCLC (adenocarcinoma and squamous cell carcinoma), (C) squamous cell carcinoma. Red and black bar indicate the high and low expression of plectin respectively. HR: hazard ratio. (D) RNAseq expression of plectin isoforms (1, 1a-1g) in NSCLC (n = 151) and SCLC+ Large Cell Neuroendocrine (NE, n = 84) cell lines. Plectin mutations were found in 14 NSCLC and 4 SCLC/NE cell lines (short bars at right).
