Figure 6

Host:target complexes. (A) Available space comparison for targets in constructs L1 and L2, which are sketched as transparent spheres in blue (construct L1, 10 Å radius) and dark green (construct L2, 20 Å radius). The host lattice is shown as a grey surface and the DARPin domains for constructs L1 and L2 as cartoons in cyan and green, respectively. The view is similar to Fig. 3D. (B) Perspective view of the crystal arrangement with EngBF-L2-DARPin_3G124 in the crystal oriented along the P6₅ symmetry axis. The symmetry elements are schematically drawn into the picture with the organisation of the unit-cell shown below the picture. EngBF-domain in pale-cyan, DARPin in orange, and the superimposed sfGFP (PDB-ID 5MA6) in green.