Table 4 Univariate and multivariate cox regression for predicting mortality.

From: Role of biomarkers as predictors of acute kidney injury and mortality in decompensated cirrhosis

 

Univariate

Multivariate

HR

95% CI

p-value

HR

95% CI

p-value

Age

1.05

1.014–1.091

0.006

1.058

0.966–1.063

0.58

Sex (male)

2.78

1.02–7.58

0.02

2.13

0.4–11.43

0.38

Hypertension

1.64

0.78–3.42

0.19

   

Diabetes mellitus

1.48

0.7–3.1

0.3

   

MELD

1.111

1.05–1.18

0.001

1.2

1.07–1.36

0.002

CRP

1.01

1.003–1.025

0.013

1.01

0.999–1.02

0.06

UPCR

1.04

0.84–1.31

0.69

   

FENa

0.87

0.55–1.35

0.523

   

Cystatin C

5

1.9–13.2

0.001

   

Corrected NGAL

1.001

0.999–1.002

0.27

   

[TIMP2][IGFBP7]/1000

1.04

0.638–1.702

0.87

   

MELD-cystatin C

1.093

1.043–1.146

<0.001

1.1

1.018–1.146

0.001

  1. Multivariate regression included Age, sex, HTN, DM, CKD, CRP and MELD or MELD using biomarker.
  2. NGAL: neutrophil gelatinase associated lipocalin, TIMP-2: tissue inhibitor of metalloproteinase-2, IGFBP7: insulin-like growth factor-binding protein7.
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