Table 2 Bivariate analysis and full multivariate model with the 12 substitution classes using logistic regression for the 4,908 tumors with a somatic substitution prevalence of ≥1 sub/Mb.

Relative frequencies of substitutions in tumors	Bivariate Analyses		Full Mutivariate Model
Relative frequencies of substitutions in tumors	Odds ratio and 95% CI	p-value	Odds ratio and 95% CI	p-value
%CA >12 vs ≤12	14.44 [11.95; 17.46]	0.001	4.86 [3.59; 6.58]	0.001
%GT >13 vs ≤13	9.17 [7.66; 10.98]	<0.001	1.62 [1.2; 2.19]	0.001
%CG ≥1 vs 0	0.45 [0.38; 0.54]	<0.001	1.52 [0.75; 3.06]	0.24
%GC ≥1 vs 0	0.50 [0.42; 0.60]	<0.001	1.58 [0.78; 3.22]	0.20
%CT	0.84 [0.83; 0.85]	<0.001	0.91 [0.88; 0.93]	<0.001
%GA	0.84 [0.83; 0.85]	<0.001	0.93 [0.91; 0.95]	<0.001
%AC	0.67 [0.63; 0.72]	<0.001	0.82 [0.76; 0.90]	<0.001
%TG	0.65 [0.61; 0.70]	<0.001	0.83 [0.76; 0.90]	<0.001
%AG >5 vs ≤5	0.23 [0.19; 0.28]	<0.001	0.43 [0.33; 0.58]	<0.001
%TC >5 vs ≤5	0.26 [0.21; 0.32]	<0.001	0.44 [0.33; 0.59]	<0.001
%AT >3 vs ≤3	1.84 [1.55; 2.17]	<0.001	0.99 [0.74; 1.33]	0.96
%TA >3 vs ≤3	2.04 [1.72; 2.40]	<0.001	1.15 [0.86; 1.53]	0.36

CI = confidence interval; vs = versus; %CA = relative frequency of C > A substitutions (%); %GT = relative frequency of G > T substitutions (%); %CG = relative frequency of C > G substitutions (%); %GC = relative frequency of G > C substitutions (%); %CT = relative frequency of C > T substitutions (%); %GA = relative frequency of G > A substitutions (%); %AC = relative frequency of A > C substitutions (%); %TG = relative frequency of T > G substitutions (%); %AG = relative frequency of A > G substitutions (%); %TC = relative frequency of T > C substitutions (%); %AT = relative frequency of A > T substitutions (%); %TA = relative frequency of T > A substitutions (%).

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