Table 3 Final logistic regression defining the EASILUNG score.

From: Somatic substitution signature as an innovative tool in lung cancer diagnosis

 

Odds Ratio‡ and 95% CI

β Coefficient‡

EASILUNG score points◊

%CA >12 vs ≤12

5.78 [4.36; 7.66]

1.7547

175

%GT >13 vs ≤13

1.86 [1.4; 2.47]

0.6209

62

%CT

0.92 [0.9; 0.94]

−0.0863

−9

%GA

0.94 [0.92; 0.96]

−0.0631

−6

%AC

0.84 [0.77; 0.92]

−0.1719

−17

%TG

0.84 [0.78; 0.92]

−0.1704

−17

%AG >5 vs ≤5

0.48 [0.36; 0.63]

−0.7433

−74

%TC >5 vs ≤5

0.48 [0.36; 0.64]

−0.7317

−73

  1. ‡Odds ratio correspond to the exponential function of the regression coefficient (eβ).
  2. ◊β Coefficient*100 rounded to the nearest integer
  3. CI = confidence interval; %CA = relative frequency of C > A substitutions (%); %GT = relative frequency of G > T substitutions (%); %CG = relative frequency of C > G substitutions (%); %GC = relative frequency of G > C substitutions (%); %CT = relative frequency of C > T substitutions (%); %GA = relative frequency of G > A substitutions (%); %AC = relative frequency of A > C substitutions (%); %TG = relative frequency of T > G substitutions (%); %AG = relative frequency of A > G substitutions (%); %TC = relative frequency of T > C substitutions (%); %AT = relative frequency of A > T substitutions (%); %TA = relative frequency of T > A substitutions (%).
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