Table 4 Mutations in HBX amplicon sequences from Tumor tissue.

From: Pro-oncogenic, intra host viral quasispecies in Diffuse large B cell lymphoma patients with occult Hepatitis B Virus infection

SN

Mutation

Type

Domain

1

A1314G

Upstream (−60)

X promoter

2

A1320G

Upstream (−54)

3

A1329A

Upstream (−45)

4

T1335C

Upstream (−39)

5

T1350C

Upstream (−24)

6

T1353G

Upstream (−21)

7

T1404C

Ser11Pro

Regulatory domain

8

A1437G

Ser22Gly

S/P rich region

X binding region

9

C1450G

Pro26Arg

10

G1464T

Ala31Ser

11

A1467G

Arg32Gly

12

G1479A

Ala36Thr

13

G1482C

Val37Leu

14

T1512G

Ser47Ala

15

C1594T*

Thr74Ile

XAP1 binding Region

16

G1630A

Arg86His

17

G1635A

Val88Ile

18

T1762A

Met130Lys

p53 binding

19

A1764G

Ile131Val

20

T1809G

Ser146Ala

21

T1812C

Ser147Pro

  1. *Unique to patient 6. All other mutations were found in all seven FFPE samples analysed.
  2. Amino acid abbreviations: Alanine (Ala), Arginine (Arg), Glycine (Gly), Histidine (His), Isoleucine (Ile), Leucine (Leu), Lysine (Lys) Methionine (Met), Proline (Pro), Serine (Ser), Threonine (Thr), Valine (Val).
Back to article page