Table 3 Overall Survival from day 200: Landmark Analysis of Potential Clinical and Echocardiographic Predictors.

From: Prognostic Value of Right Ventricular Dysfunction and Tricuspid Regurgitation in Patients with Severe Low-Flow Low-Gradient Aortic Stenosis

Parameter

Unadjusted HR

(95% CI)

Unadjusted

P - Value

Adjusted* HR (95% CI)

Adjusted*

P - Value

Partial*** PEV %

Aortic regurgitation severity

0.59 (0.25–1.39)

0.225

0.79 (0.32–1.92)

0.596

2.1

Body mass index

0.99 (0.94–1.05

0.764

0.99 (0.93–1.05)

0.777

0.0

Coronary artery disease

0.62 (0.32–1.19)

0.148

0.30 (0.14–0.68)

0.004

7.6

LV ejection fraction

0.95 (0.88–1.03)

0.198

0.97 (0.89–1.05)

0.446

0.8

Hypercholesterolemia

0.86 (0.43–1.70)

0.656

0.62 (0.29–1.33)

0.218

0.4

Hypertension

0.70 (0.37–1.35)

0.287

0.67 (0.35–1.29)

0.230

0.4

Aortic valve area**

0.91 (0.72–1.16)

0.491

0.98 (0.76–1.28)

0.938

0.0

Peak aortic-jet velocity**

0.95 (0.89–1.01)

0.075

0.96 (0.91–1.03)

0.215

1.8

Atrial fibrillation vs. SR

1.34 (0.64–2.78)

0.436

1.44 (0.69–3.00)

0.334

0.7

PM vs. SR

1.36 (0.50–3.69)

0.544

1.46 (0.53–4.97)

0.464

Left atrial diameter

1.03 (0.99–1.07)

0.121

1.03 (0.99–1.07)

0.199

2.1

Moderate-to-severe MR

1.10 (0.58–2.07)

0.778

1.13 (0.60–2.13)

0.710

0.7

Neurologic dysfunction

2.15 (0.62–7.44)

0.229

2.00 (0.58–6.90)

0.275

0.8

Peripheral artery disease

1.33 (0.70–2.55)

0.387

0.96 (0.47–1.96)

0.903

1.0

Right ventricular dysfunction

3.85 (1.92–7.70)

<0.001*

3.47 (1.70–7.09)

<0.001

11.9

Moderate-to-severe TR

2.53 (1.31–4.88)

0.006

2.23 (1.13–4.39)

0.021

5.6

Diabetes

1.41 (0.75–2.64)

0.280

1.31 (0.70–2.47)

0.395

0.8

  1. *Adjusted results from models adjusted for log of EuroSCORE II and stratified for valve intervention up to the landmark.
  2. **Effects given for steps of 0.1 (effects of remaining continuous parameters for unit steps).
  3. ***Partial PEV values give proportion of variation explained in addition to log of Baseline euroSCORE II.
  4. All results from models stratified for valve interventions up to landmark (200 days); adjusted results from models adjusted for log of Baseline euroSCORE II.
  5. P-values are not corrected for testing multiple parameters, significance after Bonferroni-Holm correction is indicated by bold face.
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