Table 3 Overall and RF-specific associations of estrogen-related polymorphisms and risk of developing erosive disease.
Gene | SNP ID | Effect allele | Overall (n = 816) | RF-positive patients (n = 571) | RF-negative patients (n = 238) | P Interaction | |||
|---|---|---|---|---|---|---|---|---|---|
OR (95% CI)† | P | OR (95% CI)† | P | OR (95% CI)† | P | ||||
CYP1A1 | rs1799814 | A | 0.85 (0.52–1.39) | 0.52 | 0.82 (0.43–1.54) | 0.53 | 0.98 (0.44–2.18) | 0.96 | 0.54 |
CYP1A2 | rs762551 | C | 0.91 (0.66–1.25) | 0.57 | 0.72 (0.48–1.09) | 0.12 | 1.37 (0.80–2.34) | 0.25 | 0.059 |
CYP1B1 | rs1800440 | G | 1.06 (0.76–1.46) | 0.74 | 1.12 (0.74–1.69) | 0.60 | 0.97 (0.55–1.69) | 0.90 | 0.50 |
CYP1B1 | rs1056836 | G | 0.92 (0.64–1.32) | 0.66 | 1.04 (0.67–1.63) | 0.85 | 0.66 (0.34–1.26) | 0.21 | 0.35 |
CYP1B1 | rs10012 | G | 0.62 (0.37–1.04)§ | 0.071 | 0.42 (0.23–0.76)§ | 0.004 | 1.70 (0.56–5.17)§ | 0.35 | 0.031 |
CYP2C9 | rs1799853 | T | 0.45 (0.20–1.02)§ | 0.056 | 0.16 (0.06–0.46)§ | 0.0007 | 2.71 (0.53–13.8)§ | 0.23 | 0.003 |
CYP2C9 | rs1057910 | C | 1.68 (0.98–2.89) | 0.059 | 2.63 (1.15–6.03) | 0.012 | 1.28 (0.58–2.81) | 0.54 | 0.20 |
CYP2C19 | rs12248560 | T | 1.04 (0.75–1.44) | 0.83 | 1.09 (0.72–1.65) | 0.70 | 0.96 (0.54–1.70) | 0.89 | 0.55 |
CYP2C19 | rs4244285 | A | 1.00 (0.69–1.44) | 0.99 | 1.02 (0.64–1.61) | 0.94 | 0.90 (0.47–1.70) | 0.74 | 0.79 |
CYP3A4 | rs2740574 | G | 1.57 (0.90–2.74) | 0.11 | 3.12 (1.29–7.55) | 0.004 | 0.70 (0.29–1.66) | 0.42 | 0.021 |
CYP3A4 | rs11773597 | C | 1.19 (0.77–1.84) | 0.43 | 1.33 (0.74–2.38) | 0.35 | 1.00 (0.50–2.03) | 0.99 | 0.65 |
CYP17A1 | rs743572 | G | 0.92 (0.66–1.28) | 0.63 | 0.99 (0.65–1.50) | 0.97 | 0.82 (0.46–1.45) | 0.49 | 0.62 |
ESR1 | rs851984 | T | 1.07 (0.78–1.46) | 0.68 | 0.82 (0.55–1.24) | 0.35 | 1.56 (0.91–2.68) | 0.10 | 0.078 |
ESR1 | rs2881766 | G | 1.00 (0.72–1.39) | 0.99 | 1.08 (0.71–1.65) | 0.71 | 0.83 (0.47–1.48) | 0.54 | 0.47 |
ESR1 | rs2071454 | G | 0.96 (0.65–1.42) | 0.82 | 1.06 (0.65–1.75) | 0.81 | 0.75 (0.38–1.49) | 0.42 | 0.41 |
ESR1 | rs2077647 | G | 0.92 (0.65–1.30) | 0.64 | 0.70 (0.45–1.09) | 0.11 | 1.46 (0.81–2.63) | 0.21 | 0.030 |
ESR1 | rs827421 | C | 0.95 (0.67–1.33) | 0.75 | 0.80 (0.52–1.25) | 0.33 | 1.21 (0.66–2.20) | 0.54 | 0.18 |
ESR1 | rs2234693 | C | 1.10 (0.78–1.55) | 0.58 | 0.97 (0.62–1.51) | 0.89 | 1.33 (0.73–2.40) | 0.35 | 0.32 |
ESR1 | rs9340799 | G | 0.97 (0.71–1.34) | 0.87 | 0.78 (0.52–1.17) | 0.23 | 1.42 (0.82–2.45) | 0.21 | 0.052 |
ESR1 | rs1801132 | G | 0.71 (0.52–0.97) | 0.034 | 0.85 (0.57–1.27) | 0.44 | 0.53 (0.31–0.92) | 0.025 | 0.13 |
ESR1 | rs3798577 | C | 1.21 (0.87–1.68) | 0.27 | 1.39 (0.92–2.10) | 0.12 | 1.12 (0.63–2.01) | 0.69 | 0.50 |
ESR1 | rs910416 | T | 0.84 (0.59–1.19) | 0.33 | 0.75 (0.47–1.18) | 0.21 | 0.91 (0.51–1.61) | 0.74 | 0.68 |
ESR2 | rs1255998 | G | 0.92 (0.64–1.33) | 0.67 | 1.07 (0.66–1.72) | 0.78 | 0.72 (0.39–1.34) | 0.30 | 0.44 |
ESR2 | rs928554 | G | 0.78 (0.52–1.17)§ | 0.23 | 0.58 (0.35–0.96)§ | 0.035 | 1.39 (0.70–2.78)§ | 0.35 | 0.032 |
ESR2 | rs4986938 | T | 1.09 (0.79–1.51) | 0.59 | 1.41 (0.93–2.11) | 0.10 | 0.74 (0.42–1.29) | 0.29 | 0.068 |
ESR2 | rs1271572 | T | 0.55 (0.37–0.82)§ | 0.004 | 0.38 (0.23–0.63)§ | 0.0002 | 1.08 (0.54–2.14)§ | 0.83 | 0.018 |
FcγR2A | rs1801274 | G | 1.04 (0.72–1.51) | 0.82 | 1.17 (0.74–1.86) | 0.50 | 0.83 (0.43–1.61) | 0.58 | 0.33 |
FcγR3A | rs396991 | C | 0.90 (0.64–1.27) | 0.56 | 1.18 (0.76–1.81) | 0.46 | 0.45 (0.24–0.85) | 0.013 | 0.028 |
GSTP1 | rs1695 | G | 1.05 (0.77–1.44) | 0.76 | 1.16 (0.77–1.75) | 0.47 | 0.70 (0.41–1.21) | 0.20 | 0.26 |
GSTP1 | rs1138272 | T | 1.32 (0.77–2.25) | 0.31 | 1.70 (0.83–3.46) | 0.13 | 0.71 (0.28–1.77) | 0.46 | 0.24 |
HSD17B1 | rs605059 | T | 1.12 (0.79–1.59) | 0.54 | 1.24 (0.80–1.92) | 0.33 | 1.12 (0.59–2.12) | 0.74 | 0.82 |
NR1I2 | rs2276706 | A | 1.01 (0.74–1.40) | 0.93 | 0.96 (0.64–1.43) | 0.83 | 1.18 (0.68–2.06) | 0.55 | 0.47 |
NR1I2 | rs1464603 | C | 1.16 (0.85–1.59) | 0.35 | 1.14 (0.76–1.69) | 0.53 | 1.45 (0.84–2.49) | 0.18 | 0.54 |
NR1I2 | rs6785049 | G | 0.92 (0.66–1.27) | 0.60 | 0.95 (0.63–1.43) | 0.81 | 1.03 (0.58–1.84) | 0.92 | 0.93 |
NR1I2 | rs2276707 | T | 1.03 (0.73–1.45) | 0.87 | 0.80 (0.51–1.23) | 0.31 | 1.62 (0.90–2.89) | 0.11 | 0.064 |
NR1I2 | rs1054191 | A | 0.83 (0.59–1.17) | 0.30 | 1.02 (0.65–1.58) | 0.94 | 0.58 (0.32–1.06) | 0.076 | 0.12 |
PGR | rs1042838 | A | 0.76 (0.53–1.08) | 0.13 | 0.74 (0.47–1.15) | 0.18 | 0.86 (0.46–1.62) | 0.64 | 0.99 |
PGR | rs1379130 | A | 0.92 (0.66–1.26) | 0.59 | 1.02 (0.68–1.53) | 0.93 | 0.79 (0.46–1.37) | 0.40 | 0.59 |
PGR | rs518162 | A | 1.11 (0.75–1.64) | 0.62 | 1.41 (0.83–2.39) | 0.21 | 0.64 (0.33–1.25) | 0.19 | 0.092 |
SHBG | rs6259 | A | 1.22 (0.83–1.78) | 0.31 | 1.87 (1.11–3.14) | 0.015 | 0.66 (0.35–1.23) | 0.19 | 0.006 |
SULT1A1 | rs9282861 | A | 1.04 (0.76–1.43) | 0.79 | 0.86 (0.58–1.29) | 0.46 | 1.38 (0.80–2.39) | 0.25 | 0.13 |
