Table 4 Replication of the most interesting associations between estrogen-related polymorphisms and risk of developing erosive disease (DREAM registry) and meta-analysis.

From: Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium

Gene	SNP ID	Effect allele	DREAM registry Overall (n = 436)			DREAM registry RF-positive patients (n = 328)			DREAM registry RF-negative patients (n = 94)			P _Interaction
Gene	SNP ID	Effect allele	OR (95% CI)^†	P		OR (95% CI)^†	P		OR (95% CI)^†	P		P _Interaction
CYP1B1	rs10012	G	0.53 (0.27–1.06)^§	0.073		0.30 (0.13–0.70)^§	0.0051		5.97 (0.70–50.6)^§	0.10		0.012
CYP2C9	rs1799853	T	NA (NA-NA)^§	NA		NA (NA-NA)^§	NA		NA (NA-NA)^§	NA		NA
CYP2C9	rs1057910	C	1.89 (0.85–4.22)	0.095		2.75 (1.03–7.35)	0.027		0.54 (0.11–2.72)	0.47		0.073
CYP3A4	rs2740574	G	0.36 (0.17–0.77)	0.008		0.42 (0.17–1.07)	0.075		0.30 (0.08–1.22)	0.098		0.58
ESR1	rs1801132	G	0.54 (0.31–0.96)^§	0.035		0.39 (0.20–0.76)^§	0.004		1.43 (0.40–5.09)^§	0.57		0.065
ESR1	rs9340799	G	0.69 (0.39–1.25)^§	0.23		0.42 (0.22–0.83)^§	0.009		8.33 (1.02–67.8)^§	0.011		0.008
ESR2	rs1255998	G	2.08 (1.17–3.69)	0.009		1.82 (0.94–3.54)	0.065		5.41 (1.15–25.4)	0.012		0.19
ESR2	rs928554	G	0.61 (0.37–1.00)	0.050		0.59 (0.33–1.07)	0.075		0.51 (0.17–1.56)	0.22		0.79
ESR2	rs1271572	T	0.90 (0.56–1.47)^§	0.68		0.78 (0.46–1.37)^§	0.41		2.16 (0.64–7.27)^§	0.19		0.32
FcγR3A	rs396991	C	0.74 (0.45–1.22)	0.25		0.78 (0.44–1.40)	0.41		0.53 (0.18–1.62)	0.27		0.58
SHBG	rs6259	A	0.86 (0.51–1.47)	0.59		1.17 (0.62–2.20)	0.63		0.22 (0.07–0.71)	0.009		0.013
Gene	SNP ID	Effect allele	REPAIR + DREAM registry Meta-analysis Overall (n = 1252)		P _Het	REPAIR + DREAM registry RF-positive patients (n = 899)		P _Het	REPAIR + DREAM registry RF-negative patients (n = 332)		P _Het
Gene	SNP ID	Effect allele	OR (95% CI) ^†	P	P _Het	OR (95% CI) ^†	P	P _Het	OR (95% CI) ^†	P	P _Het
CYP1B1	rs10012	G	0.59 (0.39–0.88)^§	0.011	0.72	0.38 (0.23–0.61)^§	0.000081	0.52	2.22 (0.83–5.95)^§	0.11	0.31
CYP2C9	rs1799853	T	NA (NA-NA)^§	NA	NA	NA (NA-NA)^§	NA	NA	NA (NA-NA)^§	NA	NA
CYP2C9	rs1057910	C	1.74 (1.11–2.73)	0.015	0.81	2.68 (1.42–5.048)	0.0022	0.95	1.08 (0.53–2.20)	0.83	0.34
CYP3A4	rs2740574	G	0.94 (0.60–1.46)	0.77	0.002	1.19 (0.63–2.25)	0.59	0.002	0.55 (0.26–1.14)	0.11	0.30
ESR1	rs1801132	G	0.75 (0.58–0.97)	0.030	0.52	0.78 (0.60–1.08)	0.13	0.51	0.72 (0.44–1.17)	0.19	0.02
ESR1	rs9340799	G	0.90 (0.68–1.19)	0.45	0.31	0.73 (0.53–1.00)	0.050	0.61	1.61 (1.00–2.58)	0.048	0.38
ESR2	rs1255998	G	1.16 (0.86–1.59)	0.33	0.02	1.28 (0.87–1.89)	0.20	0.20	0.95 (0.54–1.68)	0.86	0.02
ESR2	rs928554	G	0.70 (0.53–0.93)	0.013	0.50	0.64 (0.45–0.90)	0.013	0.73	0.77 (0.47–1.27)	0.31	0.41
ESR2	rs1271572	T	0.67 (0.49–0.91)	0.011	0.12	0.52 (0.36–0.76)^§	0.00074	0.06	1.28 (0.70–2.33)^§	0.42	0.33
FcγR3A	rs396991	C	0.85 (0.64–1.12)	0.24	0.53	1.02 (0.72–1.44)	0.93	0.26	0.47 (0.27–0.81)	0.0067	0.80
SHBG	rs6259	A	1.08 (0.79–1.48)	0.62	0.29	1.55 (1.03–2.31)	0.033	0.26	0.48 (0.28–0.83)	0.0087	0.14

Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
Data on RF was available in 422 RA patients in the replication population. Estimates were adjusted for age and sex. P ≤ 0.05 in bold.
The RF-specific effect modification of steroid hormone SNPs was determined by logistic regression using RF as interaction term.
Meta-analysis was conducted following a fixed effect model.
^†Estimates calculated according to a dominant model of inheritance.
^§Estimates calculated according to a recessive model of inheritance.

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Table 4 Replication of the most interesting associations between estrogen-related polymorphisms and risk of developing erosive disease (DREAM registry) and meta-analysis.

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