Figure 5
NKF-NK cells reduce tumor burden in mouse xenografts and improve mouse survival. (A) NKF-NK cells exhibit efficacy in a mouse sarcoma model. TC106 cells were injected subcutaneously into NSG mice. Mice were either treated weekly with vehicle (Veh) or NKF-NK cells (NK). Tumor volumes were measured on indicated days (primary tumor). 5 mice per treatment group. (B) H&E staining of resected lung tissue from Veh and NKF-NK mice at 1X magnification (metastasis). (C) Quantification of tumor in resected lung tissue based on H&E staining (metastasis). (D) Ki67 staining of resected lung tissue from Veh and NKF-NK mice at 1X magnification (metastasis). (E) Quantification of Ki67 staining in resected lung tissue (metastasis). (F) NKF-NK demonstrate efficacy in a mouse model of leukemia. Jurkat cells were injected intravenously into NSG mice. Mice were either treated weekly with vehicle (Veh) or NKF-NK cells (NK). Survival of the mice was determined. NK cells were expanded 2–5 weeks for these experiments. Data represents mean +/− SEM. *p < 0.05, **p < 0.01.
