Figure 6 | Scientific Reports

Figure 6

From: DSS-induced colitis produces inflammation-induced bone loss while irisin treatment mitigates the inflammatory state in both gut and bone

Figure 6

Dynamic cortical histomorphometry of the midshaft tibia (n = 8/group). (A) Cortical bone formation rate was lower in DSS compared with Con and Con + Ir, with DSS + Ir not different from Con or DSS alone. (B) There were not statistical differences in mineralizing surface between the four groups. (C) Mineral apposition rate was decreased in DSS compared to both Con groups while DSS + Ir was not different from Con or DSS alone. (D) Representative images of periosteal BFR in Con vs. DSS. Data are presented as mean ± SD. Bars not sharing the same letter are statistically different (p < 0.05).

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