Table 1 Conservancy analysis of high-risk HPV L1 protein.

From: In silico/In vivo analysis of high-risk papillomavirus L1 and L2 conserved sequences for development of cross-subtype prophylactic vaccine

Protein Regions

Sequence and degree of conservancy

8–22 (Type 16)

EATVYLPPVPVSKVV

16

18

31

33

35

39

45

51

52

56

58

59

68

100.00%

60.00%

100.0%

100.0%

93.33%

60.00%

60.00%

60.00%

100.0%

80.00%

100.0%

60.00%

60.00%

8–22 (Type 18)

DNTVYLPPPSVARVV

16

18

31

33

35

39

45

51

52

56

58

59

68

80.00%

100.0%

76.67%

76.67%

76.67%

90.00%

86.67%

83.33%

83.33%

73.33%

83.33%

83.33%

86.67%

95–132 (Type 16)

TQRLVWACVGVEVGRGQPLGVGISGHPLLNKLDDTENA

16

18

31

33

35

39

45

51

52

56

58

59

68

100.00%

81.58%

92.11%

86.84%

92.11%

89.47%

81.58%

84.21%

84.21%

76.32%

81.58%

86.84%

81.58%

95–132 (Type 18)

TQRLVWACAGVEIGRGQPLGVGLSGHPFYNKLDDTESS

16

18

31

33

35

39

45

51

52

56

58

59

68

81.58%

100.0%

78.95%

78.95%

81.58%

81.58%

89.47%

78.95%

81.58%

76.32%

81.58%

89.47%

89.47%

307–342 (Type 16)

FNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNM

16

18

31

33

35

39

45

51

52

56

58

59

68

100.00%

86.11%

97.22%

97.22%

97.22%

86.11%

88.89%

86.11%

100.0%

100.0%

100.0%

83.11%

86.11%

307–342 (Type 18)

FNKPYWLHKAQGHNNGVCWHNQLFVTVVDTTRSTNL

16

18

31

33

35

39

45

51

52

56

58

59

68

86.11%

100.0%

83.33%

83.33%

86.11%

91.67%

97.22%

86.11%

86.11%

86.11%

86.11%

91.67%

91.67%

398–430 (Type 16)

ILEDWNFGLQPPPGGTLEDTYRFVTSQAIACQK

16

18

31

33

35

39

45

51

52

56

58

59

68

100.00%

71.43%

85.71%

78.57%

89.29%

53.57%

67.86%

64.29%

78.57%

60.71%

78.57%

71.43%

60.71%

399–431 (Type 18)

ILEDWNFGVPPPPTTSLVDTYRFVQSVAITCQK

16

18

31

33

35

39

45

51

52

56

58

59

68

71.43%

100.0%

71.43%

71.43%

67.86%

67.86%

96.43%

60.71%

71.43%

60.71%

71.43%

89.29%

75.00%

449–473 (Type 16)

VNLKEKFSADLDQFPLGRKFLLQAG

16

18

31

33

35

39

45

51

52

56

58

59

68

100.00%

84.00%

100.0%

96.00%

96.00%

80.00%

84.00%

80.00%

96.00%

76.00%

96.00%

88.00%

88.00%

450–474 (Type 18)

VDLKEKFSLDLDQYPLGRKFLVQAG

16

18

31

33

35

39

45

51

52

56

58

59

68

84.00%

100.0%

84.00%

88.00%

88.00%

80.00%

96.43%

80.00%

88.00%

88.00%

80.00%

80.00%

84.00%

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