Table 5 The selected CTL epitopes of HPV L2 Protein, based on binding affinity.
Protein Name | Position | Epitope Sequence | No. of Alleles | Top alleles | NetMHCpan Average Rank Scores* | ProPred-I Average Scores** | Syfpeithi Average Scores** | Conservancy (= > 75%) | Allergenicity |
|---|---|---|---|---|---|---|---|---|---|
L2 | 11–20 (Type 16) | KRASATQLYK | 17 | HLA-A03:01 HLA-B58:01 HLA-B15:01 HLA-B27:05 | 0.576 | 413.070 | 17.280 | Type 31: 100% Type 33: 100% Type 35: 100% Type 51: 100% Type 52: 100% Type 58: 100% Type 56: 90% | Non-allergen |
11–20 (Type 18) | KRASVTDLYK | 17 | HLA-A03:01 HLA-B58:01 HLA-B15:01 HLA-B27:05 | 0.626 | 415.190 | 17.360 | Type 31: 100% Type 33: 100% Type 35: 100% Type 51: 100% Type 52: 100% Type 58: 100% Type 56: 90% | Non-allergen | |
60–71 (Type 18) | GTGSGTGGRTGY | 13 | HLA-A03:01 HLA-A01:01 HLA-B15:01 | 1.502 | 33.7167 | 11.585 | Type 31: 100% Type 33: 100% Type 35: 100% Type 51: 100% Type 52: 100% Type 58: 100% Type 56: 90% | Non-allergen | |
280–291 (Type 16) | DPDFLDIVALHR | 12 | HLA-A01:01 HLA-A03:01 HLA-A26:01 | 1.198 | 53.281 | 15.375 | Type 31: 100% Type 33: 100% Type 35: 100% Type 51: 100% Type 52: 100% Type 58: 100% Type 56: 90% | Non-allergen | |
293–303 (Type 16) | ALTSRRTGIRY | 10 | HLA-A01:01 HLA-A15:01 HLA-A26:01 | 0.873 | 42.308 | 14.720 | Type 31: 100% Type 33: 100% Type 35: 100% Type 51: 100% Type 52: 100% Type 58: 100% Type 56: 90% | Non-allergen | |
273–284 (Type 18) | DSDFMDIIRLHR | 12 | HLA-A40:01 HLA-A01:01 HLA-A03:01 | 1.031 | 65.570 | 14.754 | Type 31: 100% Type 33: 100% Type 35: 100% Type 51: 100% Type 52: 100% Type 58: 100% Type 56: 90% | Non-allergen | |
286–296 (Type 18) | ALTSRRGTVRF | 10 | HLA-A58:01 HLA-B27:05 HLA-B08:01 | 0.845 | 43.607 | 14.590 | Type 31: 100% Type 33: 100% Type 35: 100% Type 51: 100% Type 52: 100% Type 58: 100% Type 56: 90% | Non-allergen |
